Below you find the complete list of Tier-1-projects since the start of the regular project application programme.

8 Projects found Biology

Simulating oxygen transport through membranes at various temperatures

Date: 01.12.2017
  • Promotor(s): Oriana De Vos
  • Institution(s): UGent
  • Domain(s): Biology , Physics
Membranes are found in every cell and organelle. Oxygen must be transported through the membrane in order to supply energy to that cell/organelle. But how does oxygen diffuse through the membrane? Does the presence of ordered rafts in membranes influence this process? This project aims to investigate these questions through simulations of three model membranes with varying degree of lipid saturation, and hence varying degree of ordering. The effect of temperature will be investigated by comparing oxygen diffusion at room temperature and body temperature, which will help towards the understanding of oxygen transport in ordered rafts.

Simulating oxygen transport through membranes with various lipid compositions

Date: 01.07.2017
  • Promotor(s): Oriana De Vos
  • Institution(s): UGent
  • Domain(s): Biology , Physics
Membranes are found in every cell and organelle. Oxygen must be transported through the membrane in order to supply energy to that cell/organelle. But how does oxygen diffuse through the membrane? Does the presence of ordered rafts in membranes influence this process? This project aims to investigate these questions through simulations of three model membranes with varying degree of lipid saturation. The calculation of diffusivities converges slowly, so with long simulations, we aim at statistically significant conclusions about the effect of lipid composition on oxygen diffusion in membranes, which will help towards the understanding of oxygen transport in ordered rafts.

Effect of periodic boundary conditions on simulations of oxygen transport through membranes

Date: 01.03.2017
  • Promotor(s): Oriana De Vos
  • Institution(s): UGent
  • Domain(s): Biology , Chemistry
Membranes are found in every cell and organelle. Oxygen must be transported through the membrane in order to supply energy to that cell/organelle. But how does oxygen diffuse through the membrane? Does the presence of ordered rafts in the membrane influence this process? This project aims to investigate these questions through simulations. As a first step, the effect of periodic boundary conditions in the simulations will be examined. We will compute the oxygen diffusivities in various membranes, varying the composition, the size (volume) and the shape of the simulation box.

Molecular dynamics simulations of oxygen transport through membranes

Date: 01.11.2016
  • Promotor(s): An Ghysels
  • Institution(s): UGent
  • Domain(s): Biology
Membranes are found around every cell and organelle. Oxygen must be transported through the cell membrane in order to supply energy to the cell. The central question of this project is “how can oxygen diffuse through the membrane?” This project will investigate whether the presence of ordered rafts in the membrane have an influence on oxygen transport. We expect that the transport might be easier in ordered rafts than in disordered domains. Oxygen mobility will be examined using molecular dynamics simulations, where the initial step is the correct description of oxygen interactions at the atomic level.

Study of oxygen diffusion through cell membranes

Date: 01.03.2016
  • Promotor(s): Oriana De Vos
  • Institution(s): UGent
  • Domain(s): Biology , Physics
Everywhere in the human body, there are membranes, for instance around every cell and organelle. Oxygen must be transported through the cell membrane in order to supply energy to the cell. The central question of this project is “how can oxygen diffuse through the membrane?” This project will investigate whether the presence of ordered rafts in the membrane have an influence on oxygen transport. We expect that the transport might be easier in ordered rafts than in disordered domains. Oxygen mobility will be examined using molecular dynamics simulations, where the initial step is the correct description of oxygen interactions at the atomic level.